Anti-CCP and Diagnosing Rheumatoid Arthritis

Historical and Pathological Background

Research in rheumatoid arthritis (RA) over the past 10 years has gained significant ground in both pathophysiological and clinical understanding.

It is now known that early aggressive therapy within the first three months of the development of joint symptoms decreases the chance of developing severe disease, both clinically and radiologically.

To enable this early diagnosis, there has been considerable effort made to discover serological markers of disease.

Around 80% of RA patients become rheumatoid factor positive (IgM RF), though this can take many years to occur. In other words, IgM RF (hereafter called RF) has low sensitivity in the early stages of RA.

Furthermore, patients with other inflammatory diseases (including ...


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