PPIs for infant reflux a risk

It seemed such a godsend, didn’t it? Omeprazole for severe infant reflux. A massive improvement on the previous advice to elevate the head of the cot and nurse upright.

But since it first appeared in guidelines, there have been studies, reports and opinions cautioning against the overuse of PPIs citing everything from them being ineffectual to their potential to predispose the child to allergy.

Now it looks like there is yet another reason why we need to think again before prescribing a PPI for the distressed infant with reflux and their exhausted parents.

According to an article recently appearing in a JAMA network publication, recent study findings cast more doubt on the safety of this treatment option, suggesting that giving PPIs to infants less than six months of age is associated with a higher risk of bone fractures later in childhood.

The US researchers analysed data, including pharmacy outpatient data from over 850, ...


Lyon J. Study Questions Use of Acid Suppressors to Curb Mild Infant Reflux. JAMA 2017 Oct 17; 318(15): 1427-8. DOI: 10.1001/jama.2017.12160

Send this to a friend