Researchers question lifelong immunity to toxoplasmosis
Medical students are taught that once infected with Toxoplasma gondii—the “cat parasite”—then you’re protected from reinfection for the rest of your life. This dogma should be questioned, argue researchers in an Opinion published December 8 in Trends in Parasitology. Their concerns stem from a handful of case studies in which expectant mothers in their late 20s and early 30s were known to have been infected by T. gondii at birth but were actually found to lack immunological protection during screening.
Then there’s the mystery of the global decrease in the number of people who test positive for toxoplasmosis immunity. For example, in the 1960s, surveys of expectant mothers in France found that 80% or more had antibodies to the parasite. This number dropped to 30% in 2010 and is expected to continue falling. This change, also observed in the United States, could be due to improved food hygiene (particularly better preparation and quality of meat—beef, lamb, and venison are especially likely to carry the parasite) as well as fewer domestic cats consuming raw rodent meat and thus transmitting T. gondii to humans.
“We put forward the hypothesis that, in the past, people kept their antibodies to T. gondii because they were very likely to become re-infected,” says lead author François Peyron, a parasitologist at the Hospital Croix-Rousse in Lyon, France. “Now that the parasitic pressure has gone down, I think people are less stimulated and they lose their immunity—it’s exactly what we see for malaria.”
The uncertainty around the rate of toxoplasma infection is partly due to how infrequently it is reported. Aside from the immunocompromised, only a minority of people will experience side effects, typically flu-like symptoms, after coming into contact with the parasite. Once inside the body, the single-celled parasite travels through the blood into the brain and muscles, where it forms cysts. Researchers believe these cysts remain in an infected person for life and that their presence retriggers the immune system, but Peyron and his co-authors, Solène Rougier of Hospital Croix-Rousse and Jose Montoya of the Stanford University School of Medicine, are also challenging this idea… Read More>>
Source: Medical Xpress